This Grand Rounds Continuing Medical Education (CME) by Anthony C. Rudine, MD, MBA titled “Antenatal Glucocorticoid Exposure and the Developing Brain” was offered on November 13, 2018 at St. David’s Medical Center. Dr. Rudine discussed the effects of antenatal exposure on fetal brain development, experimental models of antenatal corticosteroid exposure and genome evaluation of exposed infants. Clinical use of antenatal synthetic glucocorticoids reduce mortality and morbidity in preterm births and to reduce the risk of respiratory distress, intraventricular hemorrhage and necrotizing enterocolitis. “Clinical research on the optimal dose regimen with respect to long-term effects on the CNS and neuro-development warrants further investigation” reports Anthony Rudine, MD, Research Medical Director of the St. David’s Medical Center, Neonatal Intensive Care Unit (NICU).